New research indicates that people who stop using blockbuster slimming jabs like Mounjaro or Wegovy may regain lost weight far faster than those who end conventional diet and exercise programs.
Published data in a prominent health publication points out that while obese individuals can lose substantial amounts of their body weight while using the jabs, the mass returns at an estimated rate of 0.8 kg per month upon discontinuation.
"Users buying such drugs need to be informed of the potential of rapid rebound weight gain when the treatment concludes," stated expert Dr. Susan Jebb.
Such speed of regain implies a return to pre-treatment mass within about one and a half years.
Comparing Approaches
The research, which examined 37 of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with other pills.
Scientists emphasize that individuals who shed pounds through dieting generally see a less rapid weight regain—perhaps 0.1 kg a month—post-intervention.
The Reason for the Quick Rebound
Nutrition scientists suggest the way of the jabs accounts for the amplified regain.
These medications imitate a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing GLP-1 concentrations several times higher than the body's typical production may cause the system to generate a reduced amount of its endogenous GLP-1, and may also diminish sensitivity to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this GLP-1 'fix' means appetite is uncontrolled, making excessive eating much more probable."
A Chronic Condition?
The NHS recommend the jabs for individuals with weight-linked health risks, accompanied by recommended lifestyle changes.
Many experts argue that, given the high risk of relapse, the therapy should be considered long-term.
This perspective is supported by drug manufacturers, who say that the findings "underscore the persistent character of obesity," similar to managing conditions like hypertension.
User Experiences
Individuals who have come off the jabs explain a intense return of hunger.
"It felt as if something activating and you're instantly starving," described a patient.
This difficulty is worsened if users have not established sustainable dietary or behavioural modifications during treatment.
Widespread Use
Survey data indicate that a significant number of people in the UK have used these injections in the past year, with desire continuing to grow.
- Use is higher among females compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- Many obtain the drugs through private healthcare rather than the NHS.
Ultimately, experts caution that while the jabs are potent tools for weight loss, they are not a standalone cure and long-term success relies on integrated lifestyle management.
